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RESEARCH & PUBLICATIONS
Research Focus
Pathologists at Path Diagnostics are actively engaging in clinical as well as translational research focusing mainly on epidemiology, pathological and molecular characteristics, and treatment response/failure mechanism in gastro-intestinal, gynecologic and hematologic cancers through the understanding their tumor immune microenvironment.
Publications
Single-cell spatial analysis of tumor immune architecture in diffuse large B cell lymphoma. Colombo A., Hav M et al. (2020). Cancer Discovery. Under Review.
Single cell transcriptome analysis reveals disease-defining T cell subsets in the tumor microenvironment of classic Hodgkin lymphoma. Aoki T, Hav M et al. Cancer Discovery. 2019 Dec. 3.
Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Cheng R, Hav M et al. 2019 Nov 4. doi: 10.1038/s41388-019-1084-z.
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Prevalence of Abnormal Cervical Cytology in HIV-Negative Women Participating in a Cervical Cancer Screening Program in Calmette Hospital, Cambodia. Hav M et al. Asian Pac J Cancer Prev. 2016;17(7):3101-3.
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Pathologic Assessment of Rectal Carcinoma after Neoadjuvant Radio(chemo)therapy: Prognostic Implications. Hav M et al. Biomed Res Int. 2015; 2015: 574540.
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Prognostic value of tumour shrinkage versus fragmentation following radiochemotheray and surgery for rectal cancer. Hav M et al. Virchows Arch. 2015 Feb 19.
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Cisplatin-modified de Gramont in second-line therapy for pancreatic adenocarcinoma. Ky V, Hav M et al. Pancreas. 2013 Oct;42(7):1138-42.
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Glypican-3 is a marker for solid pseudopapillary neoplasm of the pancreas. Hav M et al. Histopathology. 2011 Dec;59(6):1278-9.
Trans-sinusoidal portal vein embolization with ethylene vinyl alcohol copolymer (Onyx): a feasibility study in pigs. Hav M et al. Cardiovasc Intervent Radiol. 2012 Oct;35(5):1172-80.
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Colorectal cancer in Young Cambodians. Hav M et al. Asian Pac J Cancer Prev. 2011;12(4):1001-5.
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MDM2 gene amplification and protein expressions in colon carcinoma: is targeting MDM2 a new therapeutic option? Hav M et al. Virchows Arch. 2011 Feb;458(2):197-203.
Clear-cell variant of solid-pseudopapillary neoplasm of the pancreas: a case report and review of the literature. Hav M et al. Malays J Pathol. 2009 Dec;31(2):137-41.
Conference Proceedings
Highly Multiplexed Single Cell Spatial Analysis of the Tumor Microenvironment in Lymphoma Predicts Clinical Outcomes.
Monirath Hav et al. Blood (2019) 134 (Supplement_1): 2789. Presented at the American Society of Hematology (ASH) Conference, Orlando, Florida, December 2019.
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Multiplex imaging of the tumor immune microenvironment in diffuse large B cell lymphoma using Imaging Mass Cytometry. Monirath Hav, Anthony Colombo, Akil Merchant. Mass Cytometry Conference, Los Angeles, November 2019.
Highly multiplexed imaging mass cytometry reveals immune cell composition and spatial heterogeneity in diffuse large B cell lymphoma associated with treatment outcome. Monirath Hav, Erik Gerdtsson, Mohan Singh, Anthony Colombo, James Hicks, Peter Kuhnhn, Imran Siddiqi, Akil Merchant. AACR 2019, Atlanta, Georgia, April 2019.
Visualization of the tumour immune microenvironment in Hodgkin lymphoma using highly multiplexed imaging mass cytometry. Monirath Hav, Anthony Columbo, Jennifer Hwang, Erik Gerdtsson, Mohan Singh, James Hicks, Imran N. Siddiqi, Peter Kuhn, Akil A Merchant. Ming Hsieh Institute Symposium. Alhambra, California, October 2018.
IMC workflow from a Pathologist’s perspective. Monirath Hav. Second IMC User Group Meeting. Seattle, Washington, September 2018.
Colorectal cancer in Young Cambodians. Monirath Hav and Nicole Heang. International Conference of Asian Pacific Organization for Cancer Prevention; Brisbane, Australia, April 2016.
Assessment and prognostic value of regression after neoadjuvant therapy in rectal cancer: the role of tumor shrinkage and fragmentation. Monirath Hav, Claude Cuvelier, Karen Geboes, Piet Pattyn, Marleen Praet, Louis Libbrecht. Ghent Pathology 2011; Belgium, May 2011
MDM2 in colon carcinoma – gene amplification and correlation with protein expressions.
Monirath Hav, Louis Libbrecht, Piet Pattyn, Marc Peeters, Marleen Praet, Patrick Pauwels. 22nd European Congress of Pathology; Italy, September 2009.